Acetylsalicylic Acid Effect over Testicular Weight and Seminiferous Tubules Diameter

Abstract

Aim: To observe the change in testicular weight and seminiferous tubules diameter in male albino mice after ASA administration. Place and duration of study: One-year Research work at University of Health Sciences Lahore Methods: Twenty seven male adult albino mice were randomly divided into three groups, each consisting of nine animals. The control Group A was given 10 ml/kg of distilled water orally. The experimental Groups B and C were orally given Aspirin, once daily dose of 100 mg/kg and 25 mg/kg respectively. The drug administration continued for 30 days and after 24 hours of last dose all the animals were weighed, anesthetized and sacrificed. The testes from each mouse were removed, weighed and processed for H & E staining. The relative tissue body weight index was calculated with the body weight and the testes weight. Mean tubular diameter was calculated by taking the average diameter of thirty tubules from each mouse. Results: The mean of paired testicular weight, RTWI and tubular diameter was significantly raised (P value ≤ 0.05) in groups B & C as compared to control group A. Conclusion: ASA enhances the process of spermatogenesis