Preclinical assessment of analgesic, anti-inflammatory and antipyretic potential of Fragaria ananassa and Actinidia deliciosa fruit extract

Abstract

Fragaria ananassa (garden strawberry) and Actinidia deliciosa (kiwi) fruits are widely consumed due to their taste and nutritive value however several studies also supports their medicinal uses. Current study was designed to assess the In-Vivo analgesic, anti-inflammatory and antipyretic activity of ethanol extract of Fragaria ananassa (EEFA), Actinidia deliciosa (EEDA) and their 1:1 combination. Albino Wistar rats were divided into five groups (n=5) for each study comprising of vehicle control, reference standards *(aspirin and paracetamol 100 mg/kg/day), EEFA (800 mg/kg/day), EEAD (800 mg/kg/day) and 1:1 combination of EEFA and EEAD (400 + 400mg/kg/day). The results revealed significant anti-inflammatory potential of EEAD and their combination with 79.35% and 82.03% inhibition in carrageenan induced paw edema whereas 52.54% inhibition was produced by EEFA against control. However most powerful analgesic effect was produced by EEFA with 52.23% at 60 min followed by EEAD (48.38%) and EEFA+ EEAD combination (44.09%). Similarly, EEFA, EEAD and their combination also lowered the rectal temperature in highly significant manner (p≤ 0.01) against control. These results suggested the possible role of garden strawberry and kiwi in treating the ailments related to pain, inflammation and fever however further studies are required to elucidate the constituents responsible for it and their exact mechanism.