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Title: | Antimicrobial and antioxidant activity of catechin-3-o-rhamnoside isolated from the stem bark of Lannea kerstingii Engl. and K. Krause (Anacardiaceae) |
Authors: | Ngaitad Stanislaus, Njinga Mohammed Ibrahim, Sule Umar Usman, Pateh Halimatu, Hassan Sa’adiya, Sa’adiya Garba, Mohammed Toyin, Sa’ad Taibat Moji, Bakare-Odunola Roland Ndifor, Ache Godshelp Osas, Egharevba Abiodun Oyetunji, Shittu Muritala Salawu, Salawu |
Keywords: | Catechin-3-o-rhamnoside Lannea kerstingii antioxidant antimicrobial |
Issue Date: | 19-Mar-2021 |
Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
Citation: | Stanislaus, N. N., Ibrahim, S. M., Usman, P. U., Sa'adiya, H. H., Garba, M. M., Toyin, A. S. A., ... & Salawu, S. M. (2021). Antimicrobial and antioxidant activity of catechin-3-o-rhamnoside isolated from the stem bark of Lannea kerstingii Engl. and K. Krause (Anacardiaceae). Pakistan Journal of Pharmaceutical Sciences, 34(2). |
Abstract: | Various epidemiological researches have shown that consumption of vegetables and fruits are essential to maintain health and prevent diseases but the emergence of more and more drug resistance bacteria has led to high mortality. Thus the study of the antimicrobial and antioxidant activities of a flavonoid (Catechin-3-o-rhamnoside) isolated for the first time from Lannea kerstingii. Catechin-3-o-rhamnoside was isolated using dry vacuum liquid chromatography. It was characterized using 1H-NMR, 13C-NMR and 2D NMR spectra. The antimicrobial activity was determined using agar diffusion and broth dilution method. Antioxidant activity was determined through reaction of the compound with DPPH radical. The compound was active against, Methicillin Resistant Staphylococcus aureus, S. aureus, B. subtilis, E. coli, K. pneumoniae, S. typhi, S. dysentariae, C. albicans and C. tropicalis with zone of inhibition ranging from 22.0±0.1 to 35.0±0.2mm and inactive against vancomycin resistant enterococci, Proteus mirabilis and C. ulcerans. The MIC ranged from 6.25 to 12.5μg/ml while the MBC/MFC ranged from 12.5 to 50.0μg/ml. The compound showed a high radical scavenging activity with EC50 of 46.87µg/ml. These results show a potential lead drug for resistant bacteria and natural antioxidants. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/13814 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 2 |
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File | Description | Size | Format | |
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Paper-19.pd.htm | 130 B | HTML | View/Open |
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