Detection and adequacy assessment of erythrocyte glutathione transferase on the cycle toxin level of hemodialysis patient

Abstract

To explore detection and adequacy evaluation of erythrocyte glutathione S transferase (GST) in hemodialysis patients on circular toxin levels, this paper divided 84cases of long-term hemodialysis end-stage patients into 33 cases of adequate hemodialysis group (spKt/V≥1.3) and 51 cases of inadequate hemodialysis group (spKt/V<1.3) according to urea index value of unit chamber model (spKt/V). Take the other 50 cases of healthy physical examination people for control group, compare and analyze related clinical and biochemical indexes differences of three groups. The level of hemodialysis group GST, creatinine, high sensitivity C-reactive protein (hs-CRP), transferrin saturation (TSAT), parathyroid hormone (PTH), interleukin-2,6,8 (IL-2,6,8) and tumor necrosis factor-α (TNF-α) was significantly higher than the control group (P<0.05), and GST, IL-2, 6, 8, TNF-α level of inadequate hemodialysis group was significantly higher than adequate hemodialysis group (P<0.05). Pearson’s relevant analysis showed that GST and spKt/V, IL-2, IL-6, IL-8, TNF-α have positive correlation (P<0.05) and had no correlation with creatinine, hs-CRP, TSAT, PHT (P>0.05). There was 23patients spKt/V≥1.3 after adjusting the dialysis solution for 51cases of inadequate hemodialysis patients, GST level after the adjustment was significantly lower than before the adjustment, but still higher than adequate dialysis group. It concludes that the maintenance of hemodialysis patients’ level has certain relevance on spKt/V and associated inflammatory factors. Through the determination, GST can effectively response the adequate hemodialysis, which has a guiding significance on adjusting blood dialysis solution in clinic.