DSpace logo

Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/13862
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAbdul Sattar, Naila-
dc.contributor.authorHussain, Fatma-
dc.date.accessioned2022-10-28T08:07:26Z-
dc.date.available2022-10-28T08:07:26Z-
dc.date.issued2020-03-16-
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/13862-
dc.description.abstractPresent research was undertaken with the aim to assess the association of VDR gene FokI polymorphism with T2DM in local population. The study comprised of 100 T2DM patients (DG) and 50 normal individuals (CG) groups. Demographic parameters; age, gender, BMI and blood pressure were recorded. Fasting glucose (FG), HbA1c, vitamin D, liver function parameters, renal function parameters and lipid profile were measured. Significantly higher (P<0.05) BMI (34.6±11.3 vs. 24.9±4.0kg/m2 ), sBP (141±16 vs. 124±14mm Hg), dBP (81±8 vs. 76±7mm Hg), FG (145±5.54 mg/dL vs. 80±3.55mg/dL, HbA1c (7.43±0.69 % vs. 4.85±0.33%) were evident in DG as compared to CG. Prominent reduction (P<0.05) in vitamin D levels (13.69±1.85mg/dL) manifested in case subjects than that of control subjects (22.36±2.34mg/dL) as a negative correlation existed between HbA1c and vitamin D. Compared to control participants, substantially different FokI allele distribution was observed in T2DM patients. Current study s also showed no significant link between FokI genotype and the biochemical parameters. Present study endorsed the fact that diabetic patients have hypovitaminosis D and variable VDR polymorphisms. However, confirmational studies are indecisive and warrants further research.en_US
dc.language.isoenen_US
dc.publisherKarachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachien_US
dc.subjectType 2 diabetesen_US
dc.subjecthyperglycemiaen_US
dc.subjecthypovitaminosisen_US
dc.subjectVDR geneen_US
dc.subjectpolymorphismsen_US
dc.titleVitamin D receptor FokI polymorphism in a Pakistani population with type 2 diabetes mellitusen_US
dc.typeArticleen_US
Appears in Collections:Issue 2

Files in This Item:
File Description SizeFormat 
Paper-14.htm131 BHTMLView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.