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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/14051
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dc.contributor.authorJantrawut, Pensak-
dc.contributor.authorPhongpradist, Rungsinee-
dc.contributor.authorMuller, Monika-
dc.contributor.authorViernstein, Helmut-
dc.date.accessioned2022-11-17T10:26:28Z-
dc.date.available2022-11-17T10:26:28Z-
dc.date.issued2017-09-01-
dc.identifier.citationJantrawut, P., Phongpradist, R., Muller, M., & Viernstein, H. (2017). Enhancement of anti-inflammatory activity of polyphenolic flavonoid rutin by encapsulation. Pakistan Journal of Pharmaceutical Sciences, 30(5).en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/14051-
dc.description.abstractThe cellular mechanisms underlying the anti-inflammatory activity of rutin which has been found to have in vivo inhibitory effects merit more evaluation. The effects of rutin and encapsulated-rutin on lipopolysaccharide (LPS)- induced IL-6 secretion, NF-κB expression, as well as protein denaturation were investigated. The secretion of IL-6 was not found to have significantly reduced upon incubation with either rutin or encapsulated-rutin at all concentrations. At 100µg/mL, the cells treated with encapsulated-rutin brought about slightly reduced IL-6 secretion but significantly inhibited NF-kB protein expression and protein denaturation in comparison with rutin. Inflammation can be resolved through many mechanisms. The inhibition of IL-6 and NF-kB can serve not only to terminate inflammation but also to inhibit other cytokines or mechanisms. Further investigations are necessary to clarify, verify and establish the antiinflammatory mechanisms of rutin. Additionally, the encapsulation is an interesting technique for enhancing rutin activity.en_US
dc.language.isoenen_US
dc.publisherKarachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachien_US
dc.subjectRutinen_US
dc.subjectanti-inflammatory activityen_US
dc.subjectencapsulationen_US
dc.subjectflavonoiden_US
dc.titleEnhancement of anti-inflammatory activity of polyphenolic flavonoid rutin by encapsulationen_US
dc.typeArticleen_US
Appears in Collections:No.5 September, 2017

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