Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/14078
Title: A stable hydrocortisone nanosuspension for improved dissolution: Preparation, characterization and in vitro evaluation
Authors: SM Ali, Hany
Khan, Shahzeb
York, Peter
Shah, Mukarram
Khan, Jahangir
Hussain, Zahid
Ali Khan, Barkat
Keywords: Nanosuspension
Hydrocortisone
Milling
Solubility
Dissolution
Stability
Issue Date: 17-Sep-2017
Publisher: Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi
Citation: Ali, H. S., Khan, S., York, P., Shah, S. M., Khan, J., Hussain, Z., & Khan, B. A. (2017). A stable hydrocortisone nanosuspension for improved dissolution: Preparation, characterization and in vitro evaluation. Pakistan journal of pharmaceutical sciences, 30(5).
Abstract: Drug nanosuspensions have gained tremendous attraction as a platform in drug delivery. In the present work, a nanosuspension was prepared by a wet milling approach in order to increase saturation solubility and dissolution of the water insoluble drug, hydrocortisone. Size of the generated particeles was 290 nm ± 9 nm having a zeta potential of -1.9 mV ± 0.6 mV. Nanosized particles were found to have a rod shape with a narrow particle size distribution (PDI =0.17). Results of differential scanning calorimetry and X-ray diffraction analyses revealed minor modifications of crystallinity of hydrocortisone following the milling process. Solubility of hydrocortisone was enhanced by nanonization to 875µg/ml ±2.5, an almost 2.9-fold compared to the raw hydrocortisone. Moreover, the nanosuspension formulation substabtially enhanced the dissolution rate of hydrocortisone where >97% of the hydrocortisone was dissolved within 10 minutes opposed to 22.3% for the raw 50% for the raw hydrocortisone and the commercial tablet, respectively. The bioavailability study resulted in AUC 0-9h for HC nanosuspensions (31.50±2.50), which is significantly (p<0.05) higher compared to the AUC 0-9h (14.85±3.25) resulted for HC solution. The nanosuspension was physically stable at room temperature for 24 months.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/14078
ISSN: 1011-601X
Appears in Collections:No.5 September, 2017

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