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Title: | A stable hydrocortisone nanosuspension for improved dissolution: Preparation, characterization and in vitro evaluation |
Authors: | SM Ali, Hany Khan, Shahzeb York, Peter Shah, Mukarram Khan, Jahangir Hussain, Zahid Ali Khan, Barkat |
Keywords: | Nanosuspension Hydrocortisone Milling Solubility Dissolution Stability |
Issue Date: | 17-Sep-2017 |
Publisher: | Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi |
Citation: | Ali, H. S., Khan, S., York, P., Shah, S. M., Khan, J., Hussain, Z., & Khan, B. A. (2017). A stable hydrocortisone nanosuspension for improved dissolution: Preparation, characterization and in vitro evaluation. Pakistan journal of pharmaceutical sciences, 30(5). |
Abstract: | Drug nanosuspensions have gained tremendous attraction as a platform in drug delivery. In the present work, a nanosuspension was prepared by a wet milling approach in order to increase saturation solubility and dissolution of the water insoluble drug, hydrocortisone. Size of the generated particeles was 290 nm ± 9 nm having a zeta potential of -1.9 mV ± 0.6 mV. Nanosized particles were found to have a rod shape with a narrow particle size distribution (PDI =0.17). Results of differential scanning calorimetry and X-ray diffraction analyses revealed minor modifications of crystallinity of hydrocortisone following the milling process. Solubility of hydrocortisone was enhanced by nanonization to 875µg/ml ±2.5, an almost 2.9-fold compared to the raw hydrocortisone. Moreover, the nanosuspension formulation substabtially enhanced the dissolution rate of hydrocortisone where >97% of the hydrocortisone was dissolved within 10 minutes opposed to 22.3% for the raw 50% for the raw hydrocortisone and the commercial tablet, respectively. The bioavailability study resulted in AUC 0-9h for HC nanosuspensions (31.50±2.50), which is significantly (p<0.05) higher compared to the AUC 0-9h (14.85±3.25) resulted for HC solution. The nanosuspension was physically stable at room temperature for 24 months. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/14078 |
ISSN: | 1011-601X |
Appears in Collections: | No.5 September, 2017 |
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Paper-17.htm | 132 B | HTML | View/Open |
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