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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/14092
Title: Synthesis, enzyme inhibition and molecular docking studies of 1- Arylsulfonyl-4-phenylpiperazine derivatives
Authors: Athar Abbasi, Muhammad
Anwar, Ambreen
Rehman, Aziz-ur
Zahra Siddiqui, Sabahat
Rubab, Kaniz
Adnan Ali Shah, Syed
Arif Lodhi, Muhammad
Ali Khan, Farman
Ashraf, Muhammad
Alam, Umber
Keywords: Phenylpiperazine
alkyl/arylsulfonyl chlorides
enzyme inhibition activity and spectral characterization
Issue Date: 27-Sep-2017
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi
Citation: Abbasi, M. A., Anwar, A., Siddiqui, S. Z., Rubab, K., Shah, S. A. A., Lodhi, M. A., ... & Alam, U. (2017). Synthesis, enzyme inhibition and molecular docking studies of 1-arylsulfonyl-4-phenylpiperazine derivatives. Pakistan journal of pharmaceutical sciences, 30(5), 1715-1725.
Abstract: Heterocyclic molecules have been frequently investigated to possess various biological activities during the last few decades. The present work elaborates the synthesis and enzymatic inhibition potentials of a series of sulfonamides. A series of 1-arylsulfonyl-4-Phenylpiperazine (3a-n) geared up by the reaction of 1-phenylpiperazine (1) and different (un)substituted alkyl/arylsulfonyl chlorides (2a-n), under defined pH control using water as a reaction medium. The synthesized molecules were characterized by 1 H-NMR, 13C-NMR, IR and EI-MS spectral data. The enzyme inhibition study was carried on α-glucosidase, lipoxygenase (LOX), acetyl cholinesterase (AChE) and butyryl cholinesterase (BChE) enzymes supported by docking simulation studies and the IC50 values rendered a few of the synthesized molecules as moderate inhibitors of these enzymes where, the compound 3e exhibited comparatively better potency against α-glucosidase enzyme. The synthesized compounds showed weak or no inhibition against LOX, AChE and BChE enzymes.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/14092
ISSN: 1011-601X
Appears in Collections:No.5 September, 2017

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