Moxifloxacin reduces Stenotrophomonas maltophilia adhesion to mouse intestinal tract in vitro

Abstract

Stenotrophomonas maltophilia is an important opportunistic pathogen that affects immunocompromised individuals. Viable bacterial count method was used to count the number of adhered bacteria. The current study showed the efficiency of S. maltophilia (Sm2) adhesion on different parts of mouse intestinal tract (IT), small intestinal tract (SIT), large intestinal tract (LIT) and rectum (P<0.05) and this ability was equal for each part of IT [ANOVA test (P > 0.05)]. Moxifloxacin (0.03 x MIC) resulted a significant decrease in adhesion of S. maltophilia to SIT (P<0.05) versus control and other sub-inhibitory moxifloxacin concentrations (0.06 x and 1.2 x MIC). It can be concluded from the current study that the S. maltophilia (Sm2) has a good ability to adhere to mouse IT and the lowest concentrations of moxifloxacin (0.03 x MIC) reduced the ability of this bacterium to infect IT by reducing the ability of this bacterium to adhere to IT.