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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/14152
Title: CAFFEIC ACID PHENETHYL ESTER DECREASES THE LEVEL OF S-100B PROTEIN AFTER MIDDLE CEREBRAL AFTER OCCLUSION IN RABBITS
Authors: SERARSLAN, YURDAL
BAL, RAMAZAN
ENES ALTUĞ, MUHAMMED
KONTAŞ, TÜNAY
MURAT MELEK, İSMET
Keywords: Brain
caffeic acid phenethyl ester
CAPE
experimental stroke
middle cerebral artery occlusion
MCA
S100B
Issue Date: 14-Jul-2009
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi
Citation: Serarslan, Y., Bal, R., Altuğ, M. E., Kontaş, T., & Melek, I. M. (2009). CAFFEIC ACID PHENETHYL ESTER DECREASES THE LEVEL OF S-100B PROTEIN AFTER MIDDLE CEREBRAL AFTER OCCLUSION IN RABBITS. Pakistan Journal of Pharmaceutical Sciences, 22(3).
Abstract: Effects of caffeic acid phenethyl ester (CAPE) on the serum S-100B levels were studied as an index for brain damage after permanent middle cerebral artery (MCA) occlusion in rabbits. Twenty rabbits were divided into four groups (n=5): control, sham, non-treatment and CAPE. The right MCA was occluded using a microsurgical procedure with bipolar coagulation and was then transected in non-treatment and CAPE groups. The rabbits in the sham group underwent a surgical procedure but the MCA was not occluded. No surgery was performed in the control group. CAPE was administered after MCA occlusion at the dose of 10µg/kg, once a day intraperitoneally for 7 days in the CAPE group. Serum S-100B levels were determined on days 1, 2, 4 and 7. Serum S-100B level was significantly increased following permanent MCA occlusion. Posttreatment of CAPE significantly reduced the serum S-100B level. This study demonstrated that CAPE is capable of attenuating increased serum S-100B level induced by MCA occlusion in rabbits. CAPE may be useful as a neuroprotective agent.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/14152
ISSN: 1011-601X
Appears in Collections:Issue 03

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