Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/14162
Title: CEPHRADINE ANTACIDS INTERACTION STUDIES
Authors: ARAYNE, M. SAEED
SULTANA, NAJMA
AFZAL, M.
Keywords: Cephradine
antacids
simethicone
magaldrate
magnesium carbonate
magnesium hydroxide
aluminium hydroxide.
sodium bicarbonate
magnesium trisilicate
Issue Date: 20-Jul-2007
Publisher: Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.
Citation: Arayne, M. S., Sultana, N., & Afzal, M. (2007). Cephradine antacids interaction studies. Pak. J. Pharm. Sci, 20(3), 175-179.
Abstract: The present work comprises of interaction studies of cephradine with antacids. Cephradine is included among the first generation cephalosporin, which is active against a wide range of Gram positive and Gram-negative bacteria including penicillinase-producing staphylococci. Since the presence of complexing ligand may affect the bioavailability of a drug in blood or tissues, therefore, in order to study the probable interaction of cephradine with antacids all the reaction conditions were simulated to natural environments. Antacids are commonly used in patients complaining of GI irritations. The behavior of cephradine in presence of seven antacids i.e., simethicone, magaldrate, magnesium carbonate, magnesium hydroxide, magnesium trisilicate, sodium bicarbonate and aluminium hydroxide was studied by using standard dissolution apparatus. Cephradine was monitored both by UV and by high performance liquid chromatography. The results revealed that antacids containing polyvalent cations retarded the in vitro availability of cephradine. Moreover, these studies indicated that cephradine was strongly adsorbed on antacids; magnesium trisilicate and simeco® tablets (powdered) exhibited relatively higher adsorption capacities.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/14162
ISSN: 1011-601X
Appears in Collections:Issue 3

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