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http://142.54.178.187:9060/xmlui/handle/123456789/14175| Title: | ANTI-INFLAMMATORY AND ANALGESIC ALKALOID FROM SIDA CORDIFOLIA LINN. |
| Authors: | SUTRADHAR, RANAJIT KUMAR RAHMAN, AKM MATIOR AHMAD, MESBAHUDDIN BACHAR, SITESH SAHA, ACHINTO ROY, TAPASHI |
| Keywords: | Sida cordifolia analgesic anti-inflammatory activity. |
| Issue Date: | 20-Jul-2007 |
| Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
| Citation: | Sutradhar, R. K., Rahman, A. M., Ahmad, M., CHANDRA, B. S., Saha, A., & Guha, S. K. (2006). Bioactive alkaloid from Sida cordifolia Linn. with analgesic and anti-inflammatory activities. |
| Abstract: | The analgesic and anti-inflammatory activities of a new alkaloid, 1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin 3-ylamine (compound 1) isolated from Sida cordifolia Linn. were investigated in animal models. In the acetic acid induced writhing model, the compound 1 showed 25.4 (P<0.05) and 52.43% (P<0.01) inhibition of writhing response at doses of 25 and 50 mg/kg body weight respectively. The alkaloid also produced significant increase in the tail flick latency in radiant heat tail-flick method. In Carrageenan induced rat paw edema the compound 1 produced 16.93 and 24.43 % inhibition of paw edema at the doses of 25 and 50 mg/kg body weight respectively at the third hour of study. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/14175 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 3 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper-3.htm | 194 B | HTML | View/Open |
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