ANTI-INFLAMMATORY AND ANALGESIC ALKALOID FROM SIDA CORDIFOLIA LINN.

Abstract

The analgesic and anti-inflammatory activities of a new alkaloid, 1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin 3-ylamine (compound 1) isolated from Sida cordifolia Linn. were investigated in animal models. In the acetic acid induced writhing model, the compound 1 showed 25.4 (P<0.05) and 52.43% (P<0.01) inhibition of writhing response at doses of 25 and 50 mg/kg body weight respectively. The alkaloid also produced significant increase in the tail flick latency in radiant heat tail-flick method. In Carrageenan induced rat paw edema the compound 1 produced 16.93 and 24.43 % inhibition of paw edema at the doses of 25 and 50 mg/kg body weight respectively at the third hour of study.