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http://142.54.178.187:9060/xmlui/handle/123456789/14273| Title: | SYNTHESIS AND EVALUATION OF MANNICH BASES OF BENZIMIDAZO [1,2-C] QUINAZOLIN- 6(5H)-THIONE FOR ANTIMICROBIAL ACTIVITY |
| Authors: | M, SARASWATHI RM, ROHINI RANAPRATHAPSINGH, RANAPRATHAPSINGH NAYEEM, NAIRA |
| Keywords: | Mannich base Benzimidazo [1,2-c] quinazoline–6(5H)-thione antimicrobial activity |
| Issue Date: | 18-Oct-2010 |
| Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi |
| Citation: | RM, R., & Naira, N. (2010). Synthesis and evaluation of mannich bases of benzimidazo [1, 2-c] quinazolin-6 [5h]-thione for antimicrobial activity. |
| Abstract: | The intermediate Benzimidazo[1,2-c] quinazolin-6(5H)-thione (1) was obtained by cyclization of 2-(2’- aminophenyl) benzimidazole with carbon disulfide. Mannich base (2a-d) of compound (1) was obtained on treatment with Para formaldehyde and secondary aliphatic amines, similarly treatment of (1) with different ketones afforded respective mannich bases (3 e-h). All derivatives synthesized were characterized from IR and 1 HNMR spectral data’s. Moderate anti bacterial activity was exhibited from 2a-d and from 3f, 3h against S. aureus, E. coli, and E. fecalis but very negligent activity were seen from these compounds when screened against P aeruginosa |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/14273 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 04 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper-18.htm | 143 B | HTML | View/Open |
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