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Issue DateTitleAuthor(s)
2019-11-15Phenolic extracts of aerial parts of Genista ferox have been characterized and evaluated for their pharmacological properties which are still not reported. The total phenol and flavonoid contents in the extracts were estimated spectrophotometrically via the Folin-Ciocalteu and aluminium chloride methods, respectively. Leaves and pods extracts showed the highest contents of total phenols and total flavonoids. The same extracts exhibited also the highest antioxidant capacity (IC50 of 105.37µg/mL and 113.98µg/mL, respectively) assessed by the in-vitro DPPH radical scavenging method. Leave and stem extracts were explored for their possible anti-inflammatory activity assayed by carrageenan-induced paw edema model. Both extracts (at 400mg/kg) showed edema inhibitory effect, which was found to be close to that of Dichlofenac reference. However, the leave extract produced the highest significant (p<0.001) anti-inflammatory activity when compared with the control. A preliminary characterisation of these phenolic extracts were carried out by high performance liquid chromatography (HPLC) coupled with diode-array detector (DAD), in order to determine the relevance of identified compounds in the pharmacological properties of the plant.Ait-kaci Aourahoun, Karima; Fazouane, Fethia; Benayache, Samir; QBettache, Z’Hor; Benayad, Tahar; Denni, Nachida
2019-11-05The effect of Xuefu Zhuyu decoction on clopidogrel resistance and its association with the P2Y12 Gene polymorphisms and promoter DNA methylationYu, Qinglin; Su, Jia; Zhu, Keqi; Yang, Shujun; Zhu, Hao; Yu, Jingbo
2019-11-23Pharmaceutical quality evaluation of different glimepiride brands marketed in Karachi (Pakistan): In pursuance to global issue of availability and affordability of quality medicinesAli, Sidra Kanwal; Muhammad, Iyad Naeem; Siddiqui, Tuba; Zaidi, Syeda Hina; Masood, Rida
2019-12-01Role of metal ions on the catalytic efficiency of dextran hydrolyzing biocatalystShahid, Faiza; Javed, Urooj; Aman, Afsheen; Ul Qader, Shah Ali
2019-11-12Prevalence and antibiotic resistance profiles of Gram negative bacilli associated with urinary tract infections (UTIs) in Karachi, PakistanSalman Rasool, Muhammad; Siddiqui, Fraz; Ajaz, Munazza; Ajaz Rasool, Sheikh
2019-11-07Effect of 3’-4’-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in ratsKoç, Aynur; Ergene, Neyhan; Kasim Baltaci, Abdülkerim; Mogulkoc, Rasim
2019-11-04Assessment of anti-coagulant activity of Nelumbo nucifera fruitAli Rajput, Muhammad; Alam Khan, Rafeeq; Zafar, Shahid; Riaz, Azra; Ikram, Rahila
2019-11-28Antibacterial and antifungal activities of different polar extracts from Anoectochilus roxburghiiZhu, Jianjun; Yang, Jiaxin; Fang, Hailing; Zhang, Ailian; Feng, Yue; Shao, Qingsong
2019-11-19Effectiveness of Simvastatin 1% oral gel and mouthwash used as an adjunct treatment of scaling and root planning in the treatment of periodontal diseasesHasan, Faiza; Ikram, Rahila; Simjee, Shabana Usman; Iftikhar, Kanwal; Asadullah, Kamran
2019-11-08Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl) propyl]-1, 3, 4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with moderate cytotoxicityNazir, Majid; Athar Abbasi, Muhammad; ur-Rehman, Aziz; Zahra Siddiqui, Sabahat; Adnan Ali Shah, Syed; Shahid, M; Fatima, H; Iftikhar, Sunniya; Shah Zaib Saleem, Rahman