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Pakistan Journal of Pharmaceutical Sciences
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Volume 32
Issue 6
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Issue Date
Title
Author(s)
2019-11-15
Phenolic extracts of aerial parts of Genista ferox have been characterized and evaluated for their pharmacological properties which are still not reported. The total phenol and flavonoid contents in the extracts were estimated spectrophotometrically via the Folin-Ciocalteu and aluminium chloride methods, respectively. Leaves and pods extracts showed the highest contents of total phenols and total flavonoids. The same extracts exhibited also the highest antioxidant capacity (IC50 of 105.37µg/mL and 113.98µg/mL, respectively) assessed by the in-vitro DPPH radical scavenging method. Leave and stem extracts were explored for their possible anti-inflammatory activity assayed by carrageenan-induced paw edema model. Both extracts (at 400mg/kg) showed edema inhibitory effect, which was found to be close to that of Dichlofenac reference. However, the leave extract produced the highest significant (p<0.001) anti-inflammatory activity when compared with the control. A preliminary characterisation of these phenolic extracts were carried out by high performance liquid chromatography (HPLC) coupled with diode-array detector (DAD), in order to determine the relevance of identified compounds in the pharmacological properties of the plant.
Ait-kaci Aourahoun, Karima
;
Fazouane, Fethia
;
Benayache, Samir
;
QBettache, Z’Hor
;
Benayad, Tahar
;
Denni, Nachida
2019-11-05
The effect of Xuefu Zhuyu decoction on clopidogrel resistance and its association with the P2Y12 Gene polymorphisms and promoter DNA methylation
Yu, Qinglin
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Su, Jia
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Zhu, Keqi
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Yang, Shujun
;
Zhu, Hao
;
Yu, Jingbo
2019-11-23
Pharmaceutical quality evaluation of different glimepiride brands marketed in Karachi (Pakistan): In pursuance to global issue of availability and affordability of quality medicines
Ali, Sidra Kanwal
;
Muhammad, Iyad Naeem
;
Siddiqui, Tuba
;
Zaidi, Syeda Hina
;
Masood, Rida
2019-12-01
Role of metal ions on the catalytic efficiency of dextran hydrolyzing biocatalyst
Shahid, Faiza
;
Javed, Urooj
;
Aman, Afsheen
;
Ul Qader, Shah Ali
2019-11-12
Prevalence and antibiotic resistance profiles of Gram negative bacilli associated with urinary tract infections (UTIs) in Karachi, Pakistan
Salman Rasool, Muhammad
;
Siddiqui, Fraz
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Ajaz, Munazza
;
Ajaz Rasool, Sheikh
2019-11-07
Effect of 3’-4’-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in rats
Koç, Aynur
;
Ergene, Neyhan
;
Kasim Baltaci, Abdülkerim
;
Mogulkoc, Rasim
2019-11-04
Assessment of anti-coagulant activity of Nelumbo nucifera fruit
Ali Rajput, Muhammad
;
Alam Khan, Rafeeq
;
Zafar, Shahid
;
Riaz, Azra
;
Ikram, Rahila
2019-11-28
Antibacterial and antifungal activities of different polar extracts from Anoectochilus roxburghii
Zhu, Jianjun
;
Yang, Jiaxin
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Fang, Hailing
;
Zhang, Ailian
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Feng, Yue
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Shao, Qingsong
2019-11-19
Effectiveness of Simvastatin 1% oral gel and mouthwash used as an adjunct treatment of scaling and root planning in the treatment of periodontal diseases
Hasan, Faiza
;
Ikram, Rahila
;
Simjee, Shabana Usman
;
Iftikhar, Kanwal
;
Asadullah, Kamran
2019-11-08
Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl) propyl]-1, 3, 4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with moderate cytotoxicity
Nazir, Majid
;
Athar Abbasi, Muhammad
;
ur-Rehman, Aziz
;
Zahra Siddiqui, Sabahat
;
Adnan Ali Shah, Syed
;
Shahid, M
;
Fatima, H
;
Iftikhar, Sunniya
;
Shah Zaib Saleem, Rahman
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