The effects of VEGF on deep venous thrombosis in the perioperative period of elderly fracture patients

Abstract

Deep venous thrombosis is a very common complication of orthopedic patients on bed rest. In the present study, comparison of the correlation between serum vascular endothelial growth factor (VEGF) with D-Dimer, fibrinogen and thrombo elastogram was done. 68 elderly fractured patients that had undergone surgery were divided into two groups according to whether they were diagnosed with deep venous thrombosis in the perioperative period or not. ELISA assays was carried out to detect the VEGF, D-Dimer and fibrinogen levels prior to operation and post-operation on 1st, 5th& 10th day. SPSS20.0 (IBM US) statistical software was used in the research for statistical data analysis. The measured data was evaluated by using mean ± standard deviation. The present study has found that VEGF levels in both these two groups showed an increase at first followed by a decrease, which indicated that the angiogenesis process after operative injury can cause an increase of serum VEGF levels. The thrombosis group showed higher VEGF levels compared to the non-thrombosis group after the operation for different days; difference was statistically significant (P<0.05). In addition, VEGF levels in the thrombosis group after the operation were closely related to the D-Dimer and fibrinogen content. However, for non-thrombosis group, the relationship between VEGF levels and the content of DDimer and fibrinogen was weak.