Preoperative antiplatelet drugs on the hemorrhage and allogenic blood transfusion condition after coronary artery bypass graft surgery

Abstract

Aim of the study was to observe and evaluate the postoperative hemorrhage and allogenic blood transfusion condition in patients who were exposed to different levels of clopidogrel and aspirin beforeon-pump coronary artery bypass graft surgery (CABG). A total of 180 patients underwent on-pump CABG at our hospital were enrolled and divided into treatment group, discontinuation group and control group based on their preoperative use of clopidogrel and aspirin, with 60 patients in each group. And the postoperative hemorrhage and allogenic blood transfusion condition were observed and evaluated. Compared with the control group, the postoperative total drainage and the occurrence of major bleeding were significantly higher in the treatment group (p<0.05). The transfusion volume and infusion rates of packed red blood cells and fresh frozen plasma and the total blood transfusion rate were decreased progressively in accordance with the treatment group, discontinuation group and control group. The transfusion volume and infusion rates of packed red blood cells and fresh frozen plasma, and the total blood transfusion rate were significantly higher in the treatment group when compared with the control group (p<0.05). And the total blood transfusion rate was significantly higher in the treatment group when compared with the discontinuation group (p<0.05). The postoperative hemorrhage and allogenic blood transfusion rate would be significantly up-regulated when patients were exposed to clopidogrel and aspirin in the week before on-pump CABG.