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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/14532
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dc.contributor.authory de la Pena, Marcela Hurtado-
dc.contributor.authorHerrera, Rosario Covarrubias-
dc.contributor.authorRevilla Vazquez, Alma Luisa-
dc.date.accessioned2022-12-02T06:20:31Z-
dc.date.available2022-12-02T06:20:31Z-
dc.date.issued2019-11-24-
dc.identifier.citationy de la Pena, M. H., Herrera, R. C., & Vazquez, A. L. R. (2019). An exploratory study of enantioselective behavior of Sol-Gel encapsulated human serum albumin using frontal analysis. Pak. J. Pharm. Sci, 32(6), 2717-2724.en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/14532-
dc.description.abstractAdsorption behavior of pure enantiomers and racemic mixtures of nonsteroidal anti-inflammatory drugs (ibuprofen and naproxen) on human serum albumin (HSA) was evaluated. The HSA was immobilized by Sol-Gel technique and this biomaterial was used in a chromatographic system where frontal analysis experiments were performed at pH 7.4 and temperatures of 25°C and 37°C. The association constants for enantiomers of the drugs were determined by linear adjustment for data corrected just for dead volume. In uncorrected data for non-specific retention, an inverse ratio between the number of sites and the value of the association constant was found. The participation of non-specific retention was estimated by non-linear regression and the values of association constants (Kass), which were determined considering this information, are comparable to some values reported by other methods at 37°C: 1.4 x105 and 5.7 x104 for Ibuprofen (IBU) R and S, respectively, and 2.3 x105 and 1.8x105 for naproxen (NX) R and S, respectively.en_US
dc.language.isoenen_US
dc.publisherKarachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachien_US
dc.subjectAssociation constanten_US
dc.subjectfrontal analysisen_US
dc.subjectSol-Gelen_US
dc.subjectenantioselectivityen_US
dc.subjectChiral stationary phaseen_US
dc.titleAn exploratory study of enantioselective behavior of Sol-Gel encapsulated human serum albumin using frontal analysisen_US
dc.typeArticleen_US
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