Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/14537
Title: Ameliorating effect of sesamin on insulin resistance of hepatic L02 cells induced by high glucose/high insulin
Authors: Mengxi, Wang
Mo, Liu
Renjie, Zhou
Jing, Wu
Dongya, Chen
Hong, Lei
Keywords: Sesamin (SES)
insulin resistance
L02 hepatocytes
insulin receptor
IRS/PI3K/Akt signaling pathway
Issue Date: 26-Nov-2019
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi
Citation: Mengxi, W., Mo, L., Renjie, Z., Jing, W., Dongya, C., & Hong, L. (2019). Ameliorating effect of sesamin on insulin resistance of hepatic L02 cells induced by high glucose/high insulin. Pakistan Journal of Pharmaceutical Sciences, 32(6).
Abstract: Sesamin (SES) has the ameliorating effect on L02 hepatocyte model of insulin resistance induced by high glucose and high insulin, based on insulin receptor signaling pathway IRS/PI3K/Akt. Treatment with SES (200, 100µg/ml) increased glucose consumption, glucose uptake and the intracellular glycogen synthesis of L02 hepatocyte model of insulin resistance significantly. Moreover, treatment with SES promoted the gene and protein expression levels of insulin receptor (InsR) and the post-receptor associated proteins, such as insulin receptor substrate 1 (IRS1), insulin receptor substrate 2 (IRS2), PI3K (phosphatidylinositol 3-kinase), GLUT4 (glucose transporter 4) significantly, which were determined by RT-PCR and immunoblot analysis. In conclusion, SES has the ameliorating effect on L02 hepatocyte model of insulin resistance induced by high glucose/high insulin, which might be related to its effect on promoting expression of insulin receptor and its associated proteins of IRS-PI3K-Akt passway, and thus promoting insulin sensitivity.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/14537
ISSN: 1011-601X
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