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http://142.54.178.187:9060/xmlui/handle/123456789/14589| Title: | Benzothiazine based acetohydrazides and acetamides as anticancer agents |
| Authors: | Aslam, Sana Wang, Fang Ahmad, Matloob Zahoor, Ameer Fawad Mansha, Asim Rasul, Azhar Fu, Liwu |
| Keywords: | Pyrazolobenzothiazine ring system 1,2-Benzothiazine 1,1-dioxide anticancer activity |
| Issue Date: | 4-Nov-2019 |
| Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi |
| Citation: | Aslam, S., Wang, F., Ahmad, M., Zahoor, A. F., Mansha, A., Rasul, A., & Fu, L. (2019). Benzothiazine based acetohydrazides and acetamides as anticancer agents. Pak J Pharm Sci, 32(6), 2795-2800. |
| Abstract: | Four series of pyrazolobenzothiazine derivatives were evaluated for their anticancer activity against six different cancer cell lines i.e., KB (human oral carcinoma cells), MCF-7(human breast carcinoma cells), A549 (human alveolar adenocarcinoma cells), Hep-G2 (liver carcinoma cells), SGC-7901(human gastric carcinoma cells) and S1 (human colon carcinoma cells) using MTT assay. Among eighteen compounds tested, six compounds i.e., 1a, 1b, 1d, 4a, 4d and 4e were more active than 5-florouracil against human oral carcinoma cells (KB). Moreover, compounds 2b and 2c showed activity comparable to 5-FU against KB cell line. In addition, eight compounds were non-toxic to human PBM cells and thus exhibit selective anticancer activity. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/14589 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 6 (Supplementary) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 4-SUP-1228.htm | 147 B | HTML | View/Open |
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