Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/14668
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dc.contributor.authorGhufran, Hafiz-
dc.contributor.authorRiaz, Sehar-
dc.contributor.authorMahmood, Nasir-
dc.contributor.authorYaqoob, Muhammad-
dc.contributor.authorShahid, Saman-
dc.contributor.authorBhinder, Munir Ahmad-
dc.contributor.authorAnwar, Saadia-
dc.contributor.authorFaizan, Mahwish-
dc.date.accessioned2022-12-05T09:49:18Z-
dc.date.available2022-12-05T09:49:18Z-
dc.date.issued2019-09-21-
dc.identifier.citationSyedbasha, M. (2019). The immune modulatory role of interferon lambda on human B-cell functions (Doctoral dissertation, University_of_Basel).en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/14668-
dc.description.abstractWe conducted genotypic analyses of interleukin-10 (IL-10) (-1082 G/A; GG, GA, AA) and interleukin-28B (CC, CT, TT) genes polymorphisms in acute lymphoblastic leukemia (ALL) pediatric patients in descriptive study to evaluate the prevalence of these mutations. In amplification refractory mutation system-PCR (ARMS-PCR), one reaction was carried out for each patient’s DNA sample. For IL-28B gene, two forward and two reverse primers specific for Callele and T-allele were used separately. For human IL-10 gene, two different forward primers specific for A and G alleles were used in combination with common reverse primer. IL-10 gene promoter showed highest frequency (n=29, 58%) of heterozygous (GA) allele, while genotypic analysis of IL-28B gene showed highest frequency (n=28, 56%) of homozygous (CC) allele. The IL-10 (AA) genotype related to its protein’s less production in body which may be associated with the least survival of ALL’s patients, while IL-28b (CT and TT) genotypes may be associated with less IFNλ3 levels and less life expectancy.en_US
dc.language.isoenen_US
dc.publisherKarachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachien_US
dc.subjectAcute lymphoblastic leukemia (ALL)en_US
dc.subjectInterleukin 10 (IL-10)en_US
dc.subjectInterleukin 28B (IL-28B)en_US
dc.subjectSingle nucleotide polymorphism (SNP)en_US
dc.titlePolymorphism of Interleukin-10 (IL-10, -1082 G/A) and Interleukin28B (IL-28B, C/T) in pediatric Acute Lymphoblastic Leukemia (ALL)en_US
dc.typeArticleen_US
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