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DC Field | Value | Language |
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dc.contributor.author | Ghufran, Hafiz | - |
dc.contributor.author | Riaz, Sehar | - |
dc.contributor.author | Mahmood, Nasir | - |
dc.contributor.author | Yaqoob, Muhammad | - |
dc.contributor.author | Shahid, Saman | - |
dc.contributor.author | Bhinder, Munir Ahmad | - |
dc.contributor.author | Anwar, Saadia | - |
dc.contributor.author | Faizan, Mahwish | - |
dc.date.accessioned | 2022-12-05T09:49:18Z | - |
dc.date.available | 2022-12-05T09:49:18Z | - |
dc.date.issued | 2019-09-21 | - |
dc.identifier.citation | Syedbasha, M. (2019). The immune modulatory role of interferon lambda on human B-cell functions (Doctoral dissertation, University_of_Basel). | en_US |
dc.identifier.issn | 1011-601X | - |
dc.identifier.uri | http://142.54.178.187:9060/xmlui/handle/123456789/14668 | - |
dc.description.abstract | We conducted genotypic analyses of interleukin-10 (IL-10) (-1082 G/A; GG, GA, AA) and interleukin-28B (CC, CT, TT) genes polymorphisms in acute lymphoblastic leukemia (ALL) pediatric patients in descriptive study to evaluate the prevalence of these mutations. In amplification refractory mutation system-PCR (ARMS-PCR), one reaction was carried out for each patient’s DNA sample. For IL-28B gene, two forward and two reverse primers specific for Callele and T-allele were used separately. For human IL-10 gene, two different forward primers specific for A and G alleles were used in combination with common reverse primer. IL-10 gene promoter showed highest frequency (n=29, 58%) of heterozygous (GA) allele, while genotypic analysis of IL-28B gene showed highest frequency (n=28, 56%) of homozygous (CC) allele. The IL-10 (AA) genotype related to its protein’s less production in body which may be associated with the least survival of ALL’s patients, while IL-28b (CT and TT) genotypes may be associated with less IFNλ3 levels and less life expectancy. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi | en_US |
dc.subject | Acute lymphoblastic leukemia (ALL) | en_US |
dc.subject | Interleukin 10 (IL-10) | en_US |
dc.subject | Interleukin 28B (IL-28B) | en_US |
dc.subject | Single nucleotide polymorphism (SNP) | en_US |
dc.title | Polymorphism of Interleukin-10 (IL-10, -1082 G/A) and Interleukin28B (IL-28B, C/T) in pediatric Acute Lymphoblastic Leukemia (ALL) | en_US |
dc.type | Article | en_US |
Appears in Collections: | Issue 5 (Supplementary) |
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21-SUP-1203.htm | 148 B | HTML | View/Open |
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