Effect of ticagrelor on brain natriuretic peptide, heart rate and myocardial enzymes in patients with coronary atherosclerotic heart disease after stenting

Abstract

The main aim of the current work was to investigate the application of ticagrelor in patients with coronary atherosclerotic heart disease (CAHD) and its effects on brain natriuretic peptide (BNP), heart rate (HR) and myocardial enzymes. Seventy-four postoperative patients who underwent stenting for CAHD were selected as subjects, randomly divided into control group (n=37) and observation group (n=37). The control group was treated with clopidogrel after operation, while the observation group was given ticagrelor treatment. The plasma BNP, HR, myocardial zymogram and adverse cardiac events were compared between the two groups. SPSS18.0 software was used for statistical analysis and the count data was analyzed by χ2 test and the measurement data was detected by t-test The levels of BNP, HR, creatine kinase isoenzyme (CK-MB) and troponin (cTnI) in the observation group were all lower than those in the control group at 3 months after treatment (P<0.05). There was no significant difference in the incidence of myocardial infarction, angina pectoris and arrhythmia between the two groups at 3 months after treatment (P>0.05). The utilization of ticagrelor in patients with postoperative stenting for CAHD improved the BNP, HR and myocardial enzyme level in patients, and also reduced the incidence of adverse cardiac events.