Pharmacology of atorvastatin on myocardial ischemia-reperfusion in rats and drug effect analysis

Abstract

Statins are the most important drugs in the treatment of atherosclerosis. In this paper, the authors analyze the protective effect of atorvastatin on myocardial ischemia-reperfusion in rats and its drug effect. The results showed that the ratio of myocardial infarction area to total ischemia area in atorvastatin group was smaller than that in ischemia reperfusion group (P<0.01). Compared with the ischemia-reperfusion group, the MDA (16.234.05), TNF alpha (41.84 5.61) and MPO (17.542.81) were decreased in atorvastatin group. The results showed that atorvastatin could improve many hemodynamic indexes including SBP, DBP, LVSP, LVEDP and so on. To sum up, atorvastatin can affect infarct size, improve hemodynamics and left ventricular function after myocardial ischemia-reperfusion injury.