Synthesis of dihydropyrimidine stabilized silver nanoparticles with significant anti urease and catalytic applications

Abstract

We synthesized and explored biological and environmental applications of novel silver nanoparticles (AgNps) stabilized by short chain heterocyclic thiol namely Ethyl 6-methyl-4-phenyl-2-thioxo1,2,3,4-dihydropyrim-idine-5- carboxylate (DHPM). Dihydropyrimidines (DHPM), a biological active class of compounds that contain a single thiol group at the focal point which strongly stabilized the nascent AgNps. The short alkyl chain of (DHPM) effectively controlled the growth kinetics and surface morphology of AgNps. The synthesized Dihydropyrimidine stabilized silver nanoparticles (DHPM-AgNps) were investigated using Ultraviolet– visible spectroscopy (UV-Vis), Atomic force Microscopy (AFM) and Fourier-transform infrared spectroscopy (FTIR). AFM exhibited the size and shape of the DHPM-AgNps with an average diameter of 10 + 1 nm. Our prepared DHPM-AgNps were examined for urease enzyme inhibition activity. The synthesized DHPM-AgNps showed significant level of urease inhibition activity (% of inhibition 40.3±0.28%) when compared with standard thiourea inhibition activity (% of inhibition value 79.6± 0.47%.). Moreover prepared DHPM-AgNps system successfully applied for the reduction of para-nitrophenol (p-Nip). It reduces the paranitrophenol (p-Nip) to para- minophenol (p-Amp) within one second in the presence of NaBH4 under ambient temperature and pressure conditions, which followed the pseudo-first-order rate kinetics. This study will provide useful guidelines for designing efficient catalysts and stabilizing agents for Silver Nanoparticles.