Evaluation of pharmacological and toxic effects of ethanolic extract of radish pods in albino rabbits: A biochemical and histopathological study

Abstract

Radish pods are known as vegetable eaten as a part of diet. Though the pharmacologic potential of radish has been well known but there are fewer reports regarding pharmacological and toxic effects of radish pods. On account of this reason, the current study was aimed to evaluate the pharmacological and toxic effects of ethanol extract of Raphanus caudatus (radish pods) in rabbits after 60 days of administration. The plant extract was administered in 250, 500 and 1000mg/kg doses and effect was observed on hepatic, renal, cardiac and lipid profile. The extract was found to be hepatoprotective, nephroprotective and cardioprotective. Also it showed hypocholestrolemic potential at 1000 mg/kg. However at higher doses the extract presented chronic gastritis. Conversely, no indication of histological alterations was seen in other vital organs such as liver, kidneys, heart. Thus there is critical requirement to identify toxic constituent/s inducing gastritis so that safety profile of the plant can be established for effective therapeutic use.