Comparative effects of tocopherol and ubiquinol on arsenic induced nephrotoxicity in sprague dawley rats

Abstract

Millions of the people worldwide are drinking arsenic polluted water. The need of time is to find out the mitigation strategies to cope with this issue. To evaluate the effects of tocopherol and ubiquinol individually and collectively on arsenic induced nephrotoxicity in Sprague Dawley rats. 150 Sprague Dawley rats were divided into 5 groups randomly. Animals of group I were provided with distilled water and sterile diet pellets. All other groups were given arsenic contaminated water (5mg/L) ad libitum. Moreover, ubiquinol and tocopherol (250mg/kg each) were given to group III and IV rats respectively. Whereas, both tocopherol and ubiquinol (125 mg/kg each) was given to rats of group V. After 2 weeks of intervention period, serum RFTs were evaluated on micro lab. After exposure to arsenic, animals of group II showed a significant (p < 0.01) elevation of serum RFTs. Treatment with ubiquinol in group III animals and tocopherol in group IV animals reduced the levels (p <0.01) of serum RFTs in these groups. Whereas, the combined effects of both these antioxidants reversed these changes to normal values (p > 0.05). Both tocopherol and ubiquinol (synergistically) are more efficient in minimizing the nephrotoxicity induced by arsenic.