Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/14954
Title: REPORT Synergism of sodium bicarbonate and baicalin against clinical Candida albicans isolates via broth microdilution method and checkerboard assay
Authors: Shao, Jing
Xiong, Li
Zhang, Meng Xiang
Wang, Tian Ming
Wang, Chang Zhong
Keywords: Anti-candida agent
synergism
clinical isolates
sodium bicarbonate
baicalin
Issue Date: 30-May-2019
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation: Shao, J., Xiong, L., Zhang, M. X., Wang, T. M., & Wang, C. Z. (2019). Synergism of sodium bicarbonate and baicalin against clinical Candida albicans isolates via broth microdilution method and checkerboard assay. Pakistan Journal of Pharmaceutical Sciences, 32(3).
Abstract: Invasive fungal infections caused by Candida albicans constitute a prevalent worldwide health problem. Due to limited antifungal agents available, more efforts have been made towards searching the novel anti-candida drugs with low cytotoxicity. The present study was aimed to investigate the antifungal activities of baicalin and/or sodium bicarbonate (SB) against 29 C. albicans isolates including 27 clinical ones. By using broth microdilution method and checkerboard assay, it was observed that the minimum inhibitory concentrations (MICs) of baicalin and SB alone were ≥ 2048 µg/mL, and those of baicalin and SB in combination decreased 16-32 folds with fractional inhibitory concentration index (FICI) in a range of 0.094-0.375. The results presented the strong synergism between SB and baicalin in 27 clinical C. albicans isolates and provided an alternative choice against C. albicans.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/14954
ISSN: 1011-601X
Appears in Collections:2006,Part-1

Files in This Item:
File Description SizeFormat 
Paper-30.htm132 BHTMLView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.