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http://142.54.178.187:9060/xmlui/handle/123456789/14981| Title: | Synthesis, biological screening and docking studies of some indole derivatives as potential antioxidant |
| Authors: | Ansari, Sumaira Mushtaq, Nousheen Ahmed, Ahsaan Asghar, Saira Munawar, Rabya Saify, Zafar Saied |
| Keywords: | 7-azaindole 3-(2-bromoethyl)indole tryptamine, 5-hydroxytryptamine reactive oxygen species |
| Issue Date: | 20-Jul-2022 |
| Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
| Citation: | Ansari, S., Mushtaq, N., Ahmed, A., Asghar, S., Munawar, R., & Saify, Z. S. (2022). Synthesis, biological screening and docking studies of some indole derivatives as potential antioxidant. Pakistan Journal of Pharmaceutical Sciences, 35(4). |
| Abstract: | The present study envisioned some antioxidant candidates having 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole (TRY), 3-(2-bromoethyl)indole (BEI) and 7-azindole (AI) nucleus. Derivatives of these indole molecules were synthesized and their scavenging activity for reactive oxygen species (ROS) investigated by 2,2-diphenyl-1picrylhydrazyl (DPPH) radical scavenging assay. T3, T42 exhibited significant radical scavenging potential which is comparable to ascorbic acid (standard), while T36 appeared as most potent antioxidant by displaying better scavenging activity than standard molecule. Molecular docking study revealed good binding score and interactions of T36 with target human antioxidant enzyme (PDB code: 3MNG) validating the results of biological activity. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/14981 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue No.4 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 20-10348.htm | 132 B | HTML | View/Open |
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