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dc.contributor.authorSyed Kashif Zaidi-
dc.contributor.authorShakeel Ahmed Ansari-
dc.contributor.authorShams Tabrez-
dc.contributor.authorGhulam Md. Ashraf-
dc.contributor.authorShazi Shakil-
dc.contributor.authorMohammad Alam Jafri-
dc.contributor.authorMuhammad Imran Naseer-
dc.contributor.authorWesam H Abdulaal-
dc.contributor.authorNaheed Banu-
dc.contributor.authorMuhammed Al-Qahtani-
dc.date.accessioned2022-12-13T10:01:04Z-
dc.date.available2022-12-13T10:01:04Z-
dc.date.issued2019-03-07-
dc.identifier.citationZaidi, S. K., Ansari, S. A., Tabrez, S., Ashraf, G. M., Shaki, S., Jafri, M. A., ... & Al-Qahtani, M. (2019). Hepato-protective effect of Allium sativum against immobilization stress in rats. Pakistan Journal of Pharmaceutical Sciences, 32(2).en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/15012-
dc.description.abstractThe purpose of the current study was to examine immobilization stress-induced antioxidant defense changes and estimation of the antioxidant potential of pre and post stress treatment of aqueous garlic extract in rat’s liver. For this purpose, male Albino Wistar rats were treated with aqueous garlic extract both pre and after 6 h of immobilization stress. Pro-oxidant status of rat liver was evaluated by determining the levels of reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS), aspartate aminotr ansferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), glucose, uric acid and the activities of super oxide dismutase (SOD), catalase (CAT) and glutathione-Stransferase (GST). In response to 6 h of immobilization stress a significant rise in the level of above mentioned liver enzymes were recorded. However, SOD, CAT and GST enzymatic activities showed a sharp decline. The extract treatment before and after stress, almost reverted the activities of studied biochemical parameters towards their control values. Current study highlighted the antioxidant potential of garlic extracts. Based on our study, we recommend the use of garlic extract as nutritional supplement for combating oxidative stress induced damage.en_US
dc.language.isoenen_US
dc.publisherKarachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachien_US
dc.subjectStressen_US
dc.subjectgarlicen_US
dc.subjectantioxidant enzymesen_US
dc.subjectASTen_US
dc.subjectALTen_US
dc.subjectALPen_US
dc.subjectMDAen_US
dc.titleHepato-protective effect of Allium sativum against immobilization stress in ratsen_US
dc.typeArticleen_US
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