Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/15042
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBushra, Rabia-
dc.contributor.authorGhayas, Sana-
dc.contributor.authorAli, Huma-
dc.contributor.authorZafar, Farya-
dc.contributor.authorShafiq, Yousra-
dc.contributor.authorAhmed, Kamran-
dc.date.accessioned2022-12-14T03:30:56Z-
dc.date.available2022-12-14T03:30:56Z-
dc.date.issued2019-03-20-
dc.identifier.citationBushra, R., Ghayas, S., Ali, H., Zafar, F., Shafiq, Y., & Ahmed, K. (2019). Stability and in vitro release kinetic studies of cinitapride (1mg) mouth dissolving tablets. Pakistan Journal of Pharmaceutical Sciences, 32(SI2), 793-799.en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/15042-
dc.description.abstractCinitapride has been widely given in gastro-esophageal reflux disease (GERD) and dysphagia due to irregularities of GI motilities. Mouth dissolving tablets were prepared for rapid availability and action of drug. Multipoint dissolution studies were conducted in 0.1 N HCl solution of pH 1.2 and phosphate buffer of pH 4.5 and 6.8. Drug release profile showed higher liberation of cinitapride at lower pH then basic medium (<80%). Formulation containing crospovidone (10%) was found to be optimized trial having excellent quality pharmaceutical attributes. The lowest AIC, highest MSC and regression (> 0.9) values were observed for Weibull kinetics in all dissolution medium reflecting the excellent model fitting for the present study. Accelerated stability testing data showed excellent results of drug assay (>99%) along with physical characteristics indicating the absence of drug degradation as well excipient interaction. The estimated shelf life period of various optimized trial formulations was found in between 33 to 41 months.en_US
dc.language.isoenen_US
dc.publisherKarachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.en_US
dc.subjectCinitaprideen_US
dc.subjecttablets, mouth dissolving tabletsen_US
dc.subjectbiowaiver, in vitro kineticsen_US
dc.subjectstability testingen_US
dc.titleStability and in vitro release kinetic studies of cinitapride (1mg) mouth dissolving tabletsen_US
dc.typeArticleen_US
Appears in Collections:Issue 2 (Supplementary)

Files in This Item:
File Description SizeFormat 
8-SUP-1034.htm148 BHTMLView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.