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Title: | Antimicrobial potential of aqueous extract of Camellia sinensis against representative microbes |
Authors: | Ishrat Khan Tanveer Abbas Komal Anjum Syed Qamar Abbas Bibi Ibtesam Shagufta Sayed Asmat Ali Shah Najeeb Akhter Syed Shams ul Hassan |
Keywords: | Camellia sinensis drug-resistant bacteria MIC and MBC Miles and Misra |
Issue Date: | 22-Mar-2019 |
Publisher: | Karachi: Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi |
Citation: | Khan, I., Abbas, T., Anjum, K., Abbas, S. Q., Shagufta, B. I., Ali Shah, S. A., & Akhter, N. (2019). Antimicrobial potential of aqueous extract of Camellia sinensis against representative microbes. Pakistan Journal of Pharmaceutical Sciences, 32(2). |
Abstract: | Camellia sinensis is being used for decades for its therapeutic efficacies against physiological problems and microbial infections. This study was undertaken to investigate the antibacterial and antifungal potential of aqueous extract of Camellia sinensis. Antibacterial activity was determined by disc and well diffusion assay. MIC and MBC were calculated by broth dilution method. Miles and Misra technique was used to find out colony forming unit per/ml. All the test organisms revealed a diverse range of vulnerability against aqueous extract. Among Gram positive, MRSA showed to be the most sensitive with least MIC and MBC while among Gram-negative Pseudomonas aeruginosa exhibited the highest sensitivity. In Miles and Misra, a progressive decline in log of CFU/ml was observed. In time-kill assay, a decline was noted in the viable count of S.aureus after exposure to 18% aqueous extract of Camellia sinensis. In the present study aqueous extract of Camellia sinensis found to be effective against Gram positive, Gram negative and fungi. The most important finding of this study is its aqueous extract inhibitory effect against drug-resistant microorganisms e.g. MRSA and P. aeruginosa and Candida albicans. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/15063 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 2 |
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