Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/15084
Title: Depletion of apomorphine induced behavioral sensitization in rats treated with escitalopram
Authors: Farhan, Muhammad
Parveen, Mehwish
Keywords: Apomorphine
behavioral sensitization
escitalopram
psychosis
serotonin
Issue Date: 27-Jan-2019
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation: Farhan, M., & Parveen, M. (2019). Depletion of apomorphine induced behavioral sensitization in rats treated with escitalopram. Pakistan Journal of Pharmaceutical Sciences, 32(1).
Abstract: Apomorphine is a classical psychostimulant and used throughout the world as prescribed medicine. Despite of their therapeutic effects, use of psychostimulants is restricted because some psychosis and impulse control disorders are the consequence of their long term use. Studies suggest that serotonin (5-Hydroxytryptamine; 5-HT) has a critical role in psychosis and drug abuse. Center of the present article is to assess the impacts of serotonin in the easing of misuse potential; the sensitization prompted by recommended psychostimulant apomorphine. We researched that whether Escitalopram can weaken apomorphine instigated behavioral sensitization. Rats treated with Escitalopram (10 mg/kg) daily for 7 days followed by apomorphine injections (1mg/kg) for next 7 days. Apomorphine increased motor activity after single injection and repeated injections produced a progressive sensitization of motor activity. Whereas, in rats pretreated with Escitalopram apomorphine induced behavioral sensitization did not occur. In this article, from the results of this study it is concluded that apomorphine induced behavioral sensitization was smaller in rats pretreated with SSRIs. It might be due to the desensitization of somatodendritic 5-HT-1A receptors.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/15084
ISSN: 1011-601X
Appears in Collections:2006,Part-1

Files in This Item:
File Description SizeFormat 
Paper-27.htm131 BHTMLView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.