Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/15129
Title: Enriched environment palliates nicotine-induced addiction and associated neurobehavioral deficits in rats
Authors: Nawaz, Amber
Batool, Zehra
Ahmed, Saara
Tabassum, Saiqa
Khaliq, Saima
Mehdi, Bushra Jabeen
Sajid, Irfan
Ahmad, Shoaib
Saleem, Sadia
Naqvi, Fizza
Naqvi, Faizan
Haider, Saida
Keywords: Enriched environment
nicotine
addiction
locomotor activity
anxiety
memory function
Issue Date: 8-Nov-2017
Publisher: Enriched environment palliates nicotine-induced addiction and associated neurobehavioral deficits in rats
Citation: Nawaz, A., Batool, Z., Ahmed, S., Tabassum, S., Khaliq, S., Mehdi, B. J., ... & Haider, S. (2017). Enriched environment palliates nicotine-induced addiction and associated neurobehavioral deficits in rats. Pakistan Journal of Pharmaceutical Sciences, 30.
Abstract: This study was designed to investigate the role of enriched environment in preventing and/or reducing the neurobehavioral deficits produced after nicotine administration in albino Wistar rats. Equal numbers of rat in two groups were either placed in social environment (control group) or social along with physically enriched environment for four weeks before the administration of nicotine. Exposure to different environmental conditions was followed by the intraperitoneal injection of nicotine at the dose of 0.6 mg/kg for seven consecutive days during which addictive behavior was monitored using conditioned placed preference paradigm. Behavioral responses to locomotor activity, anxiety and retention of short term memory were investigated in control and nicotine injected groups exposed to different environments. Results of this study showed that the rats pre-exposed to physical along with social enrichment exhibited a decrease in drug seeking behavior, hyper locomotion, anxiogenic effects along with improvement of working memory as compared to control and nicotine injected groups that were kept in social environment alone. This behavioral study suggests that the exposure to physical enrichment along with socialization in young age can later reduce the chances of compulsive dependence on nicotine and related neurobehavioral deficits.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/15129
ISSN: 1011-601X
Appears in Collections:No.6 (Supplementary), November 2017

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