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Title: | Synthesis and antibacterial screening of S-substituted derivatives of 5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazol-2-thiol |
Authors: | Siddiqa, Asia Rehman, Aziz-ur Abbasi, Muhammad Athar Siddiqui, Sabahat Zahra Rasool, Shahid Sattar, Almas Muhammed Khan, Khalid Ahmad, Irshad Afzal, Saira |
Keywords: | 1,3,4-oxadiazole antibacterial activity piperonylic acid. |
Issue Date: | 20-Jan-2016 |
Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
Citation: | Siddiqa, A., Abbasi, M. A., Siddiqui, S. Z., Rasool, S., Sattar, A., Khan, K. M., ... & Afzal, S. (2016). Synthesis and antibacterial screening of S-substituted derivatives of 5-(3, 4-methylenedioxyphenyl)-1, 3, 4-oxadiazol-2-thiol. Pakistan Journal of Pharmaceutical Sciences, 29(1). |
Abstract: | The most emerging class among the heterocyclic compounds is 1,3,4-oxadiazoles for their diverse biological activities. In the present research work, piperonylic acid (1) was converted consecutively into corresponding ester (2), hydrazide (3) and 1,3,4-oxadiazole (4) through intermolecular cyclization. The synthesized compound 4 was subjected further to S-alkylation/aralkylation, using alkyl/aralkyl halides (5a-m) and S-substituted-1,3,4-oxadiazole derivatives were synthesized (6a-m). The structure elucidation of the synthesized molecules was processed through 1H-NMR, IR and mass spectral data. The antibacterial activity showed these molecules moderately good inhibitors of gram-negative and gram-positive bacteria. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/15140 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 01 |
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