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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/15140
Title: Synthesis and antibacterial screening of S-substituted derivatives of 5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazol-2-thiol
Authors: Siddiqa, Asia
Rehman, Aziz-ur
Abbasi, Muhammad Athar
Siddiqui, Sabahat Zahra
Rasool, Shahid
Sattar, Almas
Muhammed Khan, Khalid
Ahmad, Irshad
Afzal, Saira
Keywords: 1,3,4-oxadiazole
antibacterial activity
piperonylic acid.
Issue Date: 20-Jan-2016
Publisher: Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.
Citation: Siddiqa, A., Abbasi, M. A., Siddiqui, S. Z., Rasool, S., Sattar, A., Khan, K. M., ... & Afzal, S. (2016). Synthesis and antibacterial screening of S-substituted derivatives of 5-(3, 4-methylenedioxyphenyl)-1, 3, 4-oxadiazol-2-thiol. Pakistan Journal of Pharmaceutical Sciences, 29(1).
Abstract: The most emerging class among the heterocyclic compounds is 1,3,4-oxadiazoles for their diverse biological activities. In the present research work, piperonylic acid (1) was converted consecutively into corresponding ester (2), hydrazide (3) and 1,3,4-oxadiazole (4) through intermolecular cyclization. The synthesized compound 4 was subjected further to S-alkylation/aralkylation, using alkyl/aralkyl halides (5a-m) and S-substituted-1,3,4-oxadiazole derivatives were synthesized (6a-m). The structure elucidation of the synthesized molecules was processed through 1H-NMR, IR and mass spectral data. The antibacterial activity showed these molecules moderately good inhibitors of gram-negative and gram-positive bacteria.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/15140
ISSN: 1011-601X
Appears in Collections:Issue 01

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