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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/15143
Title: Pharmacokinetic behavior of montelukast in indigenous healthy male volunteers
Authors: Fayyaz, Amtul
Khan, Junaid Ali
Ashraf, Muhammad Mudassar
Akhter, Naheed
Aslam, Bilal
Khalid, Muhammad Fiaz
Altaf, Sidra
Naseer, Rana Dawood
Akram, Muhammad
Shah, Syed Muhammad Ali
Khadam, Muhammad Waqas
Tahir, Imtiaz Mahmood
Keywords: Kinetics
leukotriene
genetics
environmental
males
Issue Date: 18-Nov-2017
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation: Fayyaz, A., Khan, J. A., Ashraf, M. M., Akhter, N., Aslam, B., Khalid, M. F., ... & Tahir, I. M. (2017). Pharmacokinetic behavior of montelukast in indigenous healthy male volunteers. Pakistan Journal of Pharmaceutical Sciences, 30.
Abstract: Aim of present study was to investigate the pharmacokinetic behavior of Montelukast in the healthy male volunteers under indigenous conditions. One tablet of montelukast 10 mg was administered in each subject and blood at different time intervals. Concentration of montelukast in plasma samples was analyzed by high performance liquid chromatography method to calculate pharmacokinetic parameters. The plasma concentration of montelukast was in the range of 1.31-1.76µg/mL at 0.5-12 hours with Cmax value of 1.59±0.16µg/mL at 3.71±0.64 hours. These values of plasma drug concentrations were above the minimum effective concentration of montelukast during the entire study hours. Absorption and elimination half-lives of the montelukast were evaluated as 2.52±0.54 hours and 2.63±0.35 hours, respectively. The volume of distribution and total body clearance of montelukast were investigated as 0.34±0.01 L/kg and 0.01±0.00 L/hr/kg, respectively. The pharmacokinetic parameters i.e. Cmax, AUC, t1/2, Vd and ClB of montelukast calculated in present study were found different as compared to that of the previous literature values which was due to genetic and environmental variation.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/15143
ISSN: 1011-601X
Appears in Collections:No.6 (Supplementary), November 2017

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