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dc.contributor.authorKhan, Imtiaz-
dc.contributor.authorSaeed, Aamer-
dc.contributor.authorArshad, Mohammad Ifzan-
dc.contributor.authorMichael White, Jonathan-
dc.date.accessioned2022-12-15T06:12:20Z-
dc.date.available2022-12-15T06:12:20Z-
dc.date.issued2016-01-20-
dc.identifier.citationKhan, I., Saeed, A., Arshad, M. I., & White, J. M. (2016). Antimicrobial profile of some novel keto esters: Synthesis, crystal structures and structure-activity relationship studies. Pakistan Journal of Pharmaceutical Sciences, 29(1).en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/15146-
dc.description.abstractRapid increase in bacterial resistance has become a major public concern by escalating alongside a lack of development of new anti-infective drugs. Novel remedies in the battle against multidrug-resistant bacterial strains are urgently needed. So, in this context, the present work is towards the investigation of antimicrobial efficacy of some novel keto ester derivatives, which are prepared by the condensation of substituted benzoic acids with various substituted phenacyl bromides in dimethylformamide at room temperature using triethylamine as a catalyst. The structural build-up of the target compounds was accomplished by spectroscopic techniques including FTIR, 1H and 13C NMR spectroscopy and mass spectrometry. The purity of the synthesized compounds was ascertained by elemental analysis. The molecular structures of compounds (4b) and (4l) were established by X-ray crystallographic analysis. The prepared analogues were evaluated for their antimicrobial activity against Gram-positive (Staphylococcus aureus, Micrococcus leuteus) and Gramnegative (Pseudomonas picketti, Salmonella setuball) bacteria and two fungal pathogenic strains (Aspergillus niger, Aspergillus flavus), respectively. Among the screened derivatives, several compounds were found to possess significant activity but (4b) and (4l) turned out to be lead molecules with remarkable antimicrobial efficacy. The structure-activity relationship analysis of this study also revealed that structural modifications on the basic skeleton affected the antimicrobial activity of the synthesized compounds.en_US
dc.language.isoenen_US
dc.publisherKarachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.en_US
dc.subjectKeto estersen_US
dc.subjectCrystal structureen_US
dc.subjectAntimicrobial activityen_US
dc.subjectStructure-activity relationship.en_US
dc.titleAntimicrobial profile of some novel keto esters: Synthesis, crystal structures and structure-activity relationship studiesen_US
dc.typeArticleen_US
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