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http://142.54.178.187:9060/xmlui/handle/123456789/15165| Title: | A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro |
| Authors: | Gamal, Ali Ali El El Halim, Mohamed Farag Abd Kalil, Ashraf Taha Basudan, Omer Ahmed Al-Rehaily, Adnan Jathlan Ahmad, Mohamed Shamim El Tahir, Kamal Hussin Al-Massarani, Shaza Mohamed Abdel-Mageed, Wael Moustafa |
| Keywords: | Albactam Albizia lebbeck flavonoids platellete nti-aggregatory effect triterpenes |
| Issue Date: | 15-Mar-2015 |
| Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
| Citation: | El Gamal, A. A., Abd El Halim, M. F., Kalil, A. T., Basudan, O. A., Al-Rehaily, A. J., Ahmad, M. S., ... & Abdel-Mageed, W. M. (2015). A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro. Pak. J. Pharm. Sci, 28(2), 745-753. |
| Abstract: | A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs’ platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β- amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/15165 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue No.2 (Supplementary) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 15-SUP-243.htm | 147 B | HTML | View/Open |
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