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DC Field | Value | Language |
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dc.contributor.author | Yu, Qinghua | - |
dc.contributor.author | Cao, Yufei | - |
dc.contributor.author | feng Liu, Li | - |
dc.contributor.author | xiang Jiang, Shan | - |
dc.contributor.author | Yang, Qian | - |
dc.date.accessioned | 2022-12-15T06:49:10Z | - |
dc.date.available | 2022-12-15T06:49:10Z | - |
dc.date.issued | 2016-01-20 | - |
dc.identifier.citation | Yu, Q., Cao, Y., Liu, L. F., Jiang, S. X., & Yang, Q. (2016). Enhancement of sodium taurocholate to the absorption of cefquinome. Pakistan Journal of Pharmaceutical Sciences, 29(1). | en_US |
dc.identifier.issn | 1011-601X | - |
dc.identifier.uri | http://142.54.178.187:9060/xmlui/handle/123456789/15182 | - |
dc.description.abstract | The objective of the research was to detect the enhancement effect of sodium taurocholate on the absorption of cefquinome both in Caco-2 cells and rats. The absorption efficiency of cefquinome was determined by high performance liquid chromatography and calculated with apparent permeability coefficients (Papp) after Caco-2 cell monolayers treated odium taurocholate (2 mmol/L) and cefquinome. The results showed that the absorption of cefquinome in Caco-2 cell monolayers was significantly increased with the sodium taurocholate (2mmol/L). Similar results were also detected in the rats orally administrated with 1 mL PBS of cefquinome (20mg/mL) containing different concentration of sodium taurocholate (5 mmol/L, 10mmol/L and 20mmol/L) respectively. Compared with control group, sodium taurocholate at 10 and 20 mmol/L increased the absorption of cefquinome in rats from 0.26±0.04µg/mL to 0.57±0.03µg/mL, 0.78 ±0.07µg/mL respectively. These results indicated that sodium taurocholate could increase the intestinal permeability in a concentration-dependent mode, which will be useful for clinical treatment. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. | en_US |
dc.subject | Caco-2 cells | en_US |
dc.subject | cefquinome | en_US |
dc.subject | sodium taurocholate | en_US |
dc.subject | absorption | en_US |
dc.title | Enhancement of sodium taurocholate to the absorption of cefquinome | en_US |
dc.type | Article | en_US |
Appears in Collections: | Issue 01 |
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Paper-19.htm | 132 B | HTML | View/Open |
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