Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/15182
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dc.contributor.authorYu, Qinghua-
dc.contributor.authorCao, Yufei-
dc.contributor.authorfeng Liu, Li-
dc.contributor.authorxiang Jiang, Shan-
dc.contributor.authorYang, Qian-
dc.date.accessioned2022-12-15T06:49:10Z-
dc.date.available2022-12-15T06:49:10Z-
dc.date.issued2016-01-20-
dc.identifier.citationYu, Q., Cao, Y., Liu, L. F., Jiang, S. X., & Yang, Q. (2016). Enhancement of sodium taurocholate to the absorption of cefquinome. Pakistan Journal of Pharmaceutical Sciences, 29(1).en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/15182-
dc.description.abstractThe objective of the research was to detect the enhancement effect of sodium taurocholate on the absorption of cefquinome both in Caco-2 cells and rats. The absorption efficiency of cefquinome was determined by high performance liquid chromatography and calculated with apparent permeability coefficients (Papp) after Caco-2 cell monolayers treated odium taurocholate (2 mmol/L) and cefquinome. The results showed that the absorption of cefquinome in Caco-2 cell monolayers was significantly increased with the sodium taurocholate (2mmol/L). Similar results were also detected in the rats orally administrated with 1 mL PBS of cefquinome (20mg/mL) containing different concentration of sodium taurocholate (5 mmol/L, 10mmol/L and 20mmol/L) respectively. Compared with control group, sodium taurocholate at 10 and 20 mmol/L increased the absorption of cefquinome in rats from 0.26±0.04µg/mL to 0.57±0.03µg/mL, 0.78 ±0.07µg/mL respectively. These results indicated that sodium taurocholate could increase the intestinal permeability in a concentration-dependent mode, which will be useful for clinical treatment.en_US
dc.language.isoenen_US
dc.publisherKarachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.en_US
dc.subjectCaco-2 cellsen_US
dc.subjectcefquinomeen_US
dc.subjectsodium taurocholateen_US
dc.subjectabsorptionen_US
dc.titleEnhancement of sodium taurocholate to the absorption of cefquinomeen_US
dc.typeArticleen_US
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