Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/15184
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dc.contributor.authorWang, Lian-Fa-
dc.contributor.authorGu, Lei-
dc.contributor.authorXun Huang, Meng-
dc.contributor.authorBing Zhou, Wen-
dc.contributor.authorLi, Hua-
dc.contributor.authorZhu Zhang, Bang-
dc.date.accessioned2022-12-15T06:50:52Z-
dc.date.available2022-12-15T06:50:52Z-
dc.date.issued2016-01-20-
dc.identifier.citationWang, L. F., Gu, L., Huang, M. X., Zhou, W. B., Li, H., & Zhang, B. Z. (2016). Effects of spironolactone towards rabbit atrial remodeling with rapid pacing. Pakistan Journal of Pharmaceutical Sciences, 29(1), 151-157.en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/15184-
dc.description.abstractThis study aimed to observe the effects of spironolactone towards the rabbit atrial remodeling with rapid atrial pacing (RAP). 30 rabbits were randomly divided into control group, RAP group and spironolactone group, with 10 rabbits in each group. RAP was performed at the speed of 800 beats/min for 8 h, atrial effective refractory period (AERP) was determined before and at the 1st, 2nd, 4th, 6th and 8th of the pacing, the expressions of atrial muscular calcium channel α1C subunit and β1 subunit mRNA were performed the RT-PCR detection, and ultrastructural changes of atrial myocytes were observed. AERP of RAP group shortened, with poor frequency adaptability; the expressions of calcium channel α1C subunit and β1 subunit mRNA decreased 22% and 26%, respectively, when compared with the control group; ultrastructure of atrial myocytes changed significantly. AERP of spironotlactone group shortened less that RAP group, and the frequency adaptability was maintained, the decreased expressions of calcium channel α1C subunit and β1 subunit mRNA significantly reduced. RAP could cause atrial remodeling, while spironolactone could inhibit RAPinduced atrial remodeling.en_US
dc.language.isoenen_US
dc.publisherKarachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.en_US
dc.subjectFibrillationen_US
dc.subjectrapid atrial pacingen_US
dc.subjectelectrical remodelingen_US
dc.subjectstructural remodelingen_US
dc.subjectspironolactoneen_US
dc.titleEffects of spironolactone towards rabbit atrial remodeling with rapid pacingen_US
dc.typeArticleen_US
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