Please use this identifier to cite or link to this item:
http://142.54.178.187:9060/xmlui/handle/123456789/15251| Title: | Development and evaluation of immediate release diclofenac sodium suppositories |
| Authors: | Tariq Sultan Shaista Hamid Sohail Hassan Kanwal Hussain Ateka Ahmed Lubna Bashir Shazia Naz Tahmina Maqbool |
| Keywords: | Water soluble bases polyethylene glycol suppositories diclofenac sodium in vitro release study |
| Issue Date: | 3-Sep-2018 |
| Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
| Citation: | Sultan, T., Hamid, S., Hassan, S., Hussain, K., Ahmed, A., Bashir, L., ... & Pak, T. M. (2018). Development and evaluation of immediate release diclofenac sodium suppositories. Pharm. Sci, 31(5), 1791-1795. |
| Abstract: | The objective of present study was to develop and evaluate polyethylene glycol (PEG) based diclofenac sodium suppositories. This study used water soluble PEG bases (1000, 4000 and 6000) in different combinations to formulate suppositories, which were further subjected for their physicochemical properties evaluation such as weight variation, average melting point, content uniformity and disintegration. Dissolution test was used to perform the in vitro release rate studies of the suppositories. The suppository (P3) containing PEG-6000 (50%) and PEG-4000 (50%) exhibited rapid in vitro release rate of diclofenac sodium. Moreover, homogeneous distribution of diclofenac sodium is found in all six formulations. The in vitro release patterns of diclofenac sodium from the marketed Voltral suppository (100mg) and formulated suppositories were also compared and found in standard limits |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/15251 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 05 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper-3.htm | 131 B | HTML | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.