Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/15251
Title: Development and evaluation of immediate release diclofenac sodium suppositories
Authors: Tariq Sultan
Shaista Hamid
Sohail Hassan
Kanwal Hussain
Ateka Ahmed
Lubna Bashir
Shazia Naz
Tahmina Maqbool
Keywords: Water soluble bases
polyethylene glycol
suppositories
diclofenac sodium
in vitro release study
Issue Date: 3-Sep-2018
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation: Sultan, T., Hamid, S., Hassan, S., Hussain, K., Ahmed, A., Bashir, L., ... & Pak, T. M. (2018). Development and evaluation of immediate release diclofenac sodium suppositories. Pharm. Sci, 31(5), 1791-1795.
Abstract: The objective of present study was to develop and evaluate polyethylene glycol (PEG) based diclofenac sodium suppositories. This study used water soluble PEG bases (1000, 4000 and 6000) in different combinations to formulate suppositories, which were further subjected for their physicochemical properties evaluation such as weight variation, average melting point, content uniformity and disintegration. Dissolution test was used to perform the in vitro release rate studies of the suppositories. The suppository (P3) containing PEG-6000 (50%) and PEG-4000 (50%) exhibited rapid in vitro release rate of diclofenac sodium. Moreover, homogeneous distribution of diclofenac sodium is found in all six formulations. The in vitro release patterns of diclofenac sodium from the marketed Voltral suppository (100mg) and formulated suppositories were also compared and found in standard limits
URI: http://142.54.178.187:9060/xmlui/handle/123456789/15251
ISSN: 1011-601X
Appears in Collections:Issue 05

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