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Title: | Evaluation of the hepatic effect of concomitant administration of ciprofloxacin and some antimalarial drugs in Plasmodium berghei infected mice: An in vivo study |
Authors: | Amorha, Kosisochi Chinwendu Ugwuowo, Onyinyechukwu Blessing Ayogu, Ebere Emilia Nduka, Sunday Odunke Okonta, Mathew Jegbefume |
Keywords: | Artemisinin combination therapy Aspartate transaminase Ciprofloxacin Malaria Serum alanine transaminase |
Issue Date: | 5-Sep-2018 |
Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
Citation: | Amorha, K. C., Ugwuowo, O. B., Ayogu, E. E., Nduka, S. O., & Okonta, M. J. (2018). Evaluation of the hepatic effect of concomitant administration of ciprofloxacin and some antimalarial drugs in Plasmodium berghei infected mice: An in vivo study. Pakistan journal of pharmaceutical sciences, 31(5). |
Abstract: | This study evaluated the hepatotoxic effects of artesunate (AS), artemether-lumefantrine (AL) and artesunateamodiaquine (ASAQ) co-administration with ciprofloxacin (CIP) using animal model. Chloroquine sensitive Plasmodium berghei NK65 strain infected albino mice (120) were utilized for this study, carried out in three phases. Phase 1 comprised eleven groups treated with different doses of either AS, AL, ASAQ or CIP alone. Phase 2 consisted of nine groups treated with 7mg/kg of CIP combined with different doses of AS, AL, ASAQ. Phase 3 comprised ten groups treated with 14mg/kg of CIP (CIP2) with different doses of AS, AL, ASAQ. Seventy-two hours after administration of drugs, toxicity was determined by evaluating the effect of drugs on liver enzymes using spectrophotometer. Statistical analysis revealed that CIP alone significantly (P<0.05) reduced the levels of Aspartate Transaminase (AST) and Serum Alanine Transaminase (ALT) compared to AS, AL and ASAQ alone. Combination of different doses of AS, AL and ASAQ with 7mg/kg CIP significantly increased the level of AST and ALT while combination of AS, AL and ASAQ with 14mg/kg CIP significantly decreased AST and ALT levels. Care should be taken during the co-administration of low dose ciprofloxacin with artesunate, artemether-lumefantrine or artesunate-amodiaquine. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/15253 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 05 |
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File | Description | Size | Format | |
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Paper-5.htm | 131 B | HTML | View/Open |
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