Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/15284
Title: Anti-inflammatory effect of the compounds from the flowers of Trollius chinensis
Authors: Liu, Li-Jia
Hu, Xiu-Hua
Guo, Li-Na
Wang, Ru-Feng
Zhao, Qi-Tao
Keywords: Trollius chinensis
compounds
NO
IL-6
TNF-α
anti-inflammatory activity
Issue Date: 25-Sep-2018
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation: Liu, L., Hu, X., Guo, L., Wang, R., & Zhao, Q. (2018). Anti-inflammatory effect of the compounds from the flowers of Trollius chinensis. Pakistan Journal of Pharmaceutical Sciences, 131(5), 1951-1957.
Abstract: In order to investigate the anti-inflammatory activity of flavonoids, phenolic acids, and alkaloids from the flowers of Trollius chinensis, some representative compounds, namely, orientin, 2"-O-β-L-galactopyranosylorientin, vitexin, quercetin, isoquercetin, luteolin, veratric acid, proglobeflowery acid, trollioside, and trolline were selected to study their inhibitory effects against LPS-induced NO, IL-6, and TNF-α release in RAW264.7 cells. At the higher concentration, both phenolic acids and flavonoids inhibited the production of NO, whereas only phenolic acids showed this effect at the lower concentration. Although trolline had stronger cytotoxicity, it exhibited a potential effect of decreasing NO production induced by LPS in the non-toxic concentration range. In addition, all tested compounds decreased the production of IL-6 and TNF-α by almost 50% at both the higher and lower concentrations. It is concluded that the anti-inflammatory activity of the phenolic acids is stronger than that of the flavonoids.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/15284
ISSN: 1011-601X
Appears in Collections:Issue 05

Files in This Item:
File Description SizeFormat 
Paper-25.htm131 BHTMLView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.