Synthesis of novel thiazolyl-phenyl-thiazole derivatives as promising anti-Candida agents

Abstract

New imine derivatives, that contain the thiazolyl-phenyl-thiazole scaffold, were synthesized and evaluated as anti-Candida agents. Elemental analysis and FT-IR, MS, 1 H-NMR and 13C-NMR spectroscopic methods confirmed the structure of the newly synthesized compounds. The in vitro antifungal activity was investigated using the broth microdilution method against different Candida spp, including C. albicans, C. krusei and C. parapsilosis. All synthesized compounds exhibited good antifungal activity. Compound 4f showed the highest inhibitory effect against all tested Candida strains, being more potent than fluconazole. The results revealed that the new compounds have promising antifungal activity, with MIC values, ranging from 3.9 to 31.25µg/mL and MFC values between 7.81 and 62.5 µg/mL and could be considered for further development as anti-Candida agents.