Potential anti-inflammatory effect of Cissus quadrangularis L. and Lepedium sativum L. along with their combination extracts

Abstract

The anti inflammatory activity of methnolic root extract of Cissus quadrangularis L. (CQ) and seed extract of Lepedium sativum L. (LS) were studied in rats also in conjunction with using a mixture (CL) of CQ and LS. The estimation of anti-inflammatory activity was conducted by measuring volumetrically with the help of plethysmometer, the mean increase in hind paw volume of rat. Standard drug like diclofenac sodium within the dose of a 100 mg/kg is used. The doses of 50, 100 and 200 mg/kg of both plant extracts individually as well as combination were given. 0.9% NaCI (saline) solution given to control group. All the doses administered orally. Results showed that at dose of 50mg/kg showed potent activity by LS(4.06±0.03) and CQ(4.16±0.03), as CL (3.96±0.03) showed moderate activity while dose 100 and 200 mg / kg showed moderate activity by LS from respective standard i.e. Diclofenac Sodium.