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http://142.54.178.187:9060/xmlui/handle/123456789/15940| Title: | Effects of estrogen on learning-memory and expression of calbindinD28K in hippocampus in vascular dementia rats |
| Authors: | Li, Jing Zhang, Lei Li, Jiao-Jiao Xian-Qu Chen, Lin Li, Dong-Ying Li, Chun-Ying |
| Keywords: | Vascular dementia Learning- memory Hippocampus Calbindin-D28K |
| Issue Date: | 1-Jul-2017 |
| Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
| Citation: | Li, J., Zhang, L., Li, J. J., Chen, L., Li, D. Y., & Li, C. Y. (2017). Effects of estrogen on learning-memory and expression of calbindin-D28K in hippocampus in vascular dementia rats. Pakistan Journal of Pharmaceutical Sciences, 30. |
| Abstract: | Vascular dementia (VD) models were made first by repeating cerebral ischemia-reperfusion and followed by treating with estrogen. Learning-memory ability was measured by Morris water maze. Concentration of Ca2+ in hippocampus was determined by Fura-2/AM fluorescence probe and the expression of Calbindin-D28K (CB) in hippocampal CA1 was tested by immunohistochemistry. Learning-memory ability was improved in E group rats; Concentration of Ca2+ in hippocampus was decreased in E group rats. The expression of CB was less in E group rats. It implies that estrogen could improve learning-memory ability in VD rats, which may be associated with suppressing intracellular Ca2+ overload and increasing the expression of CB in hippocampus. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/15940 |
| ISSN: | 1011-601X |
| Appears in Collections: | No.4(Supplementary), July 2017 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 1-SUP-501.htm | 146 B | HTML | View/Open |
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