Clinical study of water drinking test and 24-hour intraocular pressure monitoring in patients with primary open angle glaucoma

Abstract

This paper aims to observe the relevance of 24-hour intraocular pressure (IOP) monitoring and water drinking test (WDT) in patient with primary open angle glaucoma (POAG). 55 patients (90 eyes) with POAG was selected and randomly divided into operation group an drug group. Operation group, with 30 cases (48 eyes), were treat with trabeculectomy. And the other 25 cases (42 eyes) were treat with antiglaucoma medication. 24-hour intraocular pressure and WDT were measured before treatment and 6 months after treatment. The correlation between the peak value of 24- hour intraocular pressure (IOP) and intraocular pressure (IOP) fluctuation and the drinking water test were analyzed. Pearson correlation analysis showed a strong positive correlation between the peak value of diurnal IOP and the peak value of WDT IOP (r=0.758); and the Pearson correlation analysis also showed a strong positive correlation between the peak value of diurnal IOP and the peak value of WDT IOP after 6 months of POAG surgery or drug therapy (r=0.759,0.712). The peak value of IOP and IOP fluctuation in operation group were lower than those in the drug group at 6 months after operation, the difference was statistically significant. The peak value of WDT IOP can reflect the curve peak value of 24-hour IOP, which can be used to evaluate the current treatment. There were significant differences in IOP and IOP fluctuation between the drug group and the operation group at 6 months after treatment. Operation groups could achieve lower IOP and IOP fluctuation.