Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/16066
Title: Effects of Costus speciosus ethanolic extract on male rats: The action mechanism and the ability to impregnate
Authors: Sari, Ika Puspita
Nurrochmad, Arief
Setiawan, Irfan Muris
Hertiani, Triana
Paramita, Annisa Dian
Annisa, Anggit Yustitia
Keywords: Costus extract
reproductive hormones
obstacles to pregnancy
sexual behavior
Issue Date: 5-May-2018
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation: Sari, I. P., Nurrochmad, A., Setiawan, I. M., Hertiani, T., Paramita, A. D., & Annisa, A. Y. (2018). Effects of Costus speciosus ethanolic extract on male rats: The action mechanism and the ability to impregnate. Pakistan Journal of Pharmaceutical Sciences, 31.
Abstract: To examine the action mechanism that mediates the anti-fertility effect of Costus speciosus extract, research was conducted on male Sprague-Dawley rats. Costus extract was given to male rats for 14 days at various doses, namely 275, 550 and 1,100 mg kg-1 day-1 in 0.5% sodium CMC. The results showed that Costus extract with doses ranging from 275 to 1,100 mg kg-1 day-1 was able to inhibit pregnancy among female rats by 10-70%. No obstacles in terms of sexual behavior were identified among male rats. The anti-fertility effect of Costus extract kicked in without involving a decreased level of male reproductive hormones.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/16066
ISSN: 1011-601X
Appears in Collections:Issue No.3 (Supplementary)

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