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Title: | Chronic administration of St. John’s Wort attenuates alcohol intake and brain indoleamine 2, 3-dioxygenase activity in mice |
Authors: | Warda Naseem Samina Bano |
Keywords: | Alcohol, SJW tryptophan, kynurenine IDO. |
Issue Date: | 20-Jul-2018 |
Publisher: | Karachi: Pakistan Botanical Society, University of Karachi |
Citation: | Naseem, W., & Bano, S. (2018). Chronic administration of St. John’s Wort attenuates alcohol intake and brain indoleamine 2, 3-dioxygenase activity in mice. Pak. J. Pharm. Sci, 31(4), 1203-1207. |
Abstract: | Present study aims to elucidate the effects of chronic administration of St. John’s Wort (SJW) (500mg/kg) on brain tryptophan (TRP) metabolites and indoleamine 2-3 dioxygenase (IDO) activity in alcohol treated mice. Locally bred Albino BALB/c mice, weighing 20-25g were divided into three groups (untreated controls, Alcohol, Alcohol +Drug) having 6 mice in each. Freshly prepared ethanol solution was administered in drinking water in the proportion of 5% for three days or 8% for 3 weeks to two groups. After 3 weeks drug group was treated with SJW (dissolved in ethanol: saline 1:3 v/v) at a dose of 500mg/kg was administered orally for 1 week. During treatment alcohol intake was monitored .In present finding chronic administration of SJW significantly reduced ethanol intake by 78.6% (P<0.001) in mice. Data analyzed by student‘s t-test indicates that SJW remarkably reduce kynurenine (KYN) by 60.9% (P<0.001) and KYN/TRP ratio (IDO) activity) by 70.9% (P<0.001) in brain. Low serotonin level promotes alcohol intake. Present results suggest that SJW decreases alcohol intake by inhibiting IDO thereby shifting TRP catabolism towards serotonin synthesis. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16148 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 04 |
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