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Title: | Antioxidant and xanthine oxidase inhibitory activity of Eucommia ulmoides Oliver leaf extracts |
Authors: | Guiming Fu Huoyan Tong Hailong Zeng Bin Zou Jianxin Chai Lunning Zhang Mingyong Xie Feng Chen Yin Wan |
Keywords: | E. ulmoides leaf extracts total phenolics total flavonoids antioxidant activity xanthine oxidase inhibitory activity. |
Issue Date: | 20-Jul-2018 |
Publisher: | Karachi: Pakistan Botanical Society, University of Karachi |
Citation: | Guiming, F., Huoyan, T., Hailong, Z., Bin, Z., Jianxin, C., Lunning, Z., ... & Yin, W. (2018). Antioxidant and xanthine oxidase inhibitory activity of Eucommia ulmoides oliver leaf extracts. |
Abstract: | The total phenolic content, flavonoid content, in vitro xanthine oxidase (XOD) inhibitory activity and antioxidant activity (AA) of Eucommia ulmoides Oliver leaf extracts were investigated. The AA investigations included 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, β-carotene/linoleic acid bleaching assay and oxygen radical absorbance capacity (ORAC) test. The ethyl acetate fraction (EE) showed the highest AA and xanthine oxidase inhibitory activity. Whilst the lowest 50% inhibition (IC50) value of this fraction for DPPH free radical scavenging was 0.045mg/mL, its highest ORAC value was 10.57 µmol TE/mg. The highest inhibition rate against linoleic acid oxidation observed was 69.41%, and the lowest IC50 value for xanthine oxidase activity inhibition was 2.47mg/mL. These results show that E. ulmoides leaf extract is a promising source of natural antioxidants because it contains high contents of bioactive compounds, including chlorogenic acid, rutin, hyperin and astragalin, as detected by high-performance liquid chromatography coupled to HPLC-DAD-ESI-MS. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16173 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 04 |
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Paper-18.htm | 132 B | HTML | View/Open |
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